Histamine, Hormones, and Menstrual Migraines: Estrogen fluctuations can influence histamine levels. This may explain why: Migraines worsen before menstruation, Some women develop migraines in perimenopause, Hormonal shifts trigger headaches. If your migraines are hormone-related, histamine may be part of the mechanism. At Healing Response Acupuncture & Functional Neurology, our approach focuses on calming the nervous system, reducing inflammation, so migraines become less fre